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When Canadian researchers randomly assigned 47 postmenopausal women to two groupsresistance training (three days/week for 12 months) plus creatine supplementation or resistance training plus placebo, those in the creatine group were more successful in staving off bone loss at the femoral neck (the tip-top of the thighbone, a hotspot for osteoporotic fractures)

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Cognitive decline and memory problems Reduced BDNF levels correlate directly with impaired memory performance, particularly episodic and declarative memory