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The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain

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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT)a metabolic regulator tied to fat storage, NAD depletion, and reduced energy expenditure

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