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Metal chelators, including quinolines and thiosemicarbazones, have shown broad antitumor activity and potential in overcoming MDR by modulating metal metabolism

Prasad K, Mishra M

[DOI] [PubMed] [Google Scholar] 99.Dutra F., Knudsen F.S., Curi D., Bechara E.J

In the endoplasmic reticulum (ER), oxidative protein folding through the ER oxidoreductin 1 (ERO1)- protein disulfide isomerase (PDI) axis continuously generates H 2 O 2 , which is locally contained and recycled by peroxiredoxin 4 (PRDX4) and the glutathione (GSH)/thioredoxin (Trx) system (Fig

Vitamin E also exhibits protective effects against other pollutants such as Benzo[a]pyrene (BaP), acrolein, and aluminum nanopowder by preventing oxidative stress [89,90,91]