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Methodology Literature searches were conducted in PubMed and Google Scholar databases

Open questions include tissue-selective delivery, chronic dosing effects on one-carbon metabolism, and interactions with NAD precursor strategies [14,8,9]

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B Vitamins are water-soluble and excess is excreted through the urine

The consequences of B12 deficiency can be grave

More on this: Vegan and vegetarian sources of B12 To diagnose a vitamin B12 deficiency, doctors A doctor may order blood tests if they suspect a person has a vitamin B12 deficiency, including a complete blood count and tests to check levels of B12 and folate in the blood