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Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complications associated with these diseases

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In addition to the mentioned syndromes [5,6,7], BPC 157 provided beneficial effects in the duodenal venous congestion lesions [8], perforated cecum [9], damaged peritoneum [10], ischemia/reperfusion colitis [11], and bile duct ligation-induced liver cirrhosis and portal hypertension [12]

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