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DNA methylation intratumor heterogeneity in localized lung adenocarcinomas

doi: 10.1371/journal.pone.0208806

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Antigen-specific T cells generally reside in TAM-rich regions of the TME and T cell-TAM interactions contribute to T cell exhaustion programs or prevent TIL infiltration into the tumor nests 242, 243, 244 In contrast, cDCs, although more rare, are a prognostic marker and correlate with the number of stem-like Texh-prog cells 60, 245, 246

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