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Cyclic 3-Hydroxymelatonin, a Key Metabolite Enhancing the Peroxyl Radical Scavenging Activity of Melatonin

Park BJ, Jung YJ, Ro YS, Chang SE, Kim JE

This 30-60 minute pre-bed window allows adequate time for subcutaneous absorption, peptide circulation to the pituitary, receptor binding and signaling cascade activation, and initiation of growth hormone secretion increase that peaks around natural sleep onset timing

GLP-1 is a hormone naturally produced in the body that is involved in blood sugar regulation and appetite signaling

Holmstrm KM, Finkel T

10.1016/j.ynpai.2020.100046