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The activity of LCAT requires interaction with apoA-I, which remains on the surface of HDL as they get larger through protein, cholesterol, and triglyceride acquisition

Contrastingly, studies have shown that intrathecal administration can be a balanced approach, providing better cell migration to the central nervous system with reduced invasiveness [151]

Intrastriatal Injection of Preformed Alpha-Synuclein Fibrils Alters Central and Peripheral Immune Cell Profiles in Non-Transgenic Mice

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doi: 10.1161/ATVBAHA.108.179333