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10.1161/JAHA.120.018633 Summary Keywords intracranial aneurysm, DNA methylation, mRNA expression, 5-aza-2'-deoxycytidine, glutathione S-tranferase alpha 4 Citation Xu T, Yu X, Zhou S, Wu Y, Deng X, Wu Y, Wang S, Gao X, Nie S, Zhou C, Sun J and Huang Y (2023) DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner

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After two weeks, there was an increase in glutathione levels and insulin sensitivity

This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications