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Moreover, persistent hyperglycaemia triggers activation of the (NF-B) pathway and release of pro-inflammatory factors, leading to an imbalance between the pro- and anti-inflammatory networks, resulting in an increase in reactive oxygen species and the production of a large number of inflammatory mediators, which affects the functioning of the mitochondria and leads to neuronal damage and degeneration (29)

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These findings suggest that local side-chain composition near Asp524 may critically influence the efficacy of EAR-20

[DOI] [PMC free article] [PubMed] [Google Scholar] 192.Briones M.R.S., Snyder A.M., Ferreira R.C., Neely E.B., Connor J.R., Broach J.R

We sincerely thank all collaborating authors for their valuable contributions, insightful discussions, and collective efforts throughout the preparation of this manuscript

[Google Scholar] 43.Duvall C
