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Enzymatic hydrolysis within the stomach and small intestine rapidly cleaves peptide bonds, while epithelial tight junctions restrict paracellular transport of larger, hydrophilic molecules

[14] Carbamoyl phosphate synthetase complex Another well-characterized example of substrate channeling is the bacterial carbamoyl phosphate synthetase complex, which catalyzes the synthesis of carbamoyl phosphate, required for pyrimidine and arginine synthesis
The authors provided the treatment

However, practical limits exist from injection volume, local reactions, or systemic effects

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For both reactions, the methyl group of the SAM is either transferred to a lysine or arginine residue of a histone protein or to the 5-carbon atom of the pyrimidine base cytosine, producing S-adenosyl-homocysteine (SAH) [11]
