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It was demonstrated that icv administration of the melanocortin ligands Ac-Nle-Asp-Trp-DPhe-Nle-Trp-Lys-NH 2 (pA 2 =8.4 in the frog skin assay, IC 50 = 260, 60, and 910 nM at the hMC3R, hMC4R, and hMC5R) respectively or c[Gly-Cpg-DNal(2)-Arg-Trp-Glu]-Val-Val-Gly-NH 2 (K i = 53 nM at the hMC1R by Schild analysis, IC 50 = 12, 44, and 1300 nM at the hMC3R, hMC4R, and hMC5R, respectively) potentiated -opioid analgesia in female but not male mice [178, 188, 189]

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Other Ingredients: Hydroxypropyl Methylcellulose (Vegetable Capsule), Magnesium Stearate, Sorbitol, Calcium Silicate, Silicon Dioxide