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In addition, it was found that the destruction of CXCR2-NHERF1-PLC-3 complex can significantly inhibit the progression of pancreatic malignant tumors in vitro and in vivo (45)

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Interestingly, the pentamer changes into the monomeric form after interacting with activated membranes through a procedure involving an intermediate CRP form known as monomeric CRP m or pentameric CRP*, a form which represents the initial stages of subunit dissociation, in which the still-pentameric protein begins expressing antigenic and functional attributes, which are characteristic of monomeric CRP [68]
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