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The same methodology previously used for dietary antioxidant studies can be applied to inhaled antioxidants, although inter-subject differences in inhalation technique, breathing patterns, and variability in nebulizer output present unique challenges to aerosol treatment

Destabilizing mutations facilitate this initial transition, and the increased rate of conversion to a pathological state likely contributes to the earlier age of onset compared with wild-type TTR amyloidosis

Nat Rev Endocrinol 13:161

S2CID 40296724

Gilbert D, Colton C, editor