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Alternatively, serine can be converted to 3-hydroxypyruvate via transamination of pyruvate catalyzed by alanineglyoxylate and serinepyruvate aminotransferase 2 (encoded by the AGXT2 gene)

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Consequently, to shed further light on the pathophysiology of -thalassemia and propose fresh ideas for its therapy, this paper reviews ferroptosis, ineffective erythropoiesis, and the way they interact