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After binding to skin basement membrane zone antigens, pathogenic antibodies activate complement, induce inflammatory cell invasion, and cause inflammatory damage, which leads to the formation of subepidermal blisters ( Aging and chronic pigmentary disorders Previous research has indicated that premature aging is linked to vitiligo and melasma ( Figure 5 )

In addition to pain, symptoms include a tingling or burning sensation, numbness, and muscle weakness

Studies have shown significantly reduced GPX3 mRNA levels in chondrocytes from KBD patients, where elevated methylation of CpGs in the GPX3 gene suppresses its transcription, reducing antioxidant function and promoting chondrocyte apoptosis, thus accelerating KBD progression [205,206]

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367 Interestingly, overexpression of ZIP1 can sensitize the tumorigenic prostate epithelial cells (RWPE2) to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis