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It is usual to start therapy with published dosage recommendations, generally beginning at the lower end of the recommended dosage range and monitoring for a therapeutic effect

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This creates an individualized optimization challenge: finding the lowest dose that produces satisfactory results while minimizing adverse effects

Increased ACSL4 expression is observed in tumors, particularly triple-negative breast cancer, where higher ACSL4 levels may enhance sensitivity to radiotherapy and chemotherapy [31]

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Qualitatively, both self-report and EHR data showed similar distributions for weight loss efficacy (Extended Data Fig