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In addition to counteracting the effects of PM in the initial processes of pathogen recognition and innate immunity activation, B12 also inhibits disease effects in canonical pathways that directly regulate the major component of neuroinflammation ( Neuroinflammation Signaling Pathway, IL6 Signaling , Integrin Signaling , and Leukocyte Extravasation Signaling, Production of NO and ROS in macrophages , and Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes ) ( Figure 2B , Additional File 3 )
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