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Introduction The prevalence of cancer continues to rise globally, with the World Health Organization estimating that 1 in 5 people will develop cancer in their lifetime

Additionally, in atherosclerotic lesions, NOX4-produced ROS drives monocyte and macrophage cell death 77 a vital step required to prevent prolonged inflammation in wound healing 78

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Prolonged nicotine use leads to reward effects and makes nicotine a highly addictive component found in almost all tobacco products

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