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There is a need for personalized treatment/mechanism-based approaches for DPN, which includes the targeted interventions based on the comorbid risk factors and underlying disease mechanisms specific to each patient, besides the optimal diabetes treatment ALA is an effective first-line disease-modifying antioxidant therapy for long-term management of DPN

Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stem cells

MIC + B12 injections may be appropriate for individuals who want additional support for energy, nutrient metabolism, and consistency during weight loss

Several studies reported inverse correlations between dietary choline or betaine intake or their plasma levels and homocysteine bioavailability in humans

Chen W, Lin F, Feng X, Yao Q, Yu Y, Gao F, et al

Rationale for choosing 50 g dose of vitamin B 12 Based on results from previous studies in this area, we expect the intake of vitamin B 12 among women in our study to be low, both due to a predominant plant-based diet and poor gut function that again may disturb vitamin B 12 absorption and increase dose requirements