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Front Immunol 13:863234 Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

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Systemic administration of cytokines, such as TNF and IL-18, were shown to cause anorexia by directly targeting receptors in the central nervous system, most notably in the Stria Terminalis [30,31]

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They show promising results in animal studies, but human evidence is limited, so we cannot confirm real clinical benefit

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