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When the T-cell receptor of these potentially autoreactive CD4 and CD8 T cells encounters the auto/self-peptide in the grooves of the two HLA molecules expressed on the plasma membrane of the medullary thymic epithelial cells, the autoreactive T cells receive the kiss of death and more than 90% of them die by apoptosis in the first days of life

Once acetoacetate reaches extrahepatic tissues, it is converted back to acetyl- CoA that can enter the citric acid cycle to produce ATP

Protective effect of lipoic acid against chloroquineinduced hepatotoxicity in rats