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Interestingly, loss of KEAP1 has been shown to be due to an immunosuppressive tumor microenvironment, leading to a deficiency of tumor-infiltrating lymphocytes (TILs) and Natural Killer (NK) cells in mice with lung cancer, suggesting a link with NRF2 hyperactivity and immune evasion.47 LKB1 activates the AMPK and KEAP1/NRF2 signaling, which increases the expression of PD-L1 in NSCLC.48 A large database study found that the patients with KEAP1-NFE2L2 mutations who underwent ICIs had shorter OS than wild type and that KEAP1-mutant NSCLC is associated with higher TMB.49 It indicates ICIs may not be beneficial for NSCLC patients with KEAP1-NFE2L2 mutations despite high TMB

oxidative stress, complement system, fibrosis) might be a promising therapeutic strategy to improve the quality of various donor organs and expand organ availability

Tanshinone IIA Induces Ferroptosis in Gastric Cancer Cells through P53-Mediated SLC7A11 Down-Regulation

This discovery might have implications also for SnCE2-5 for which no enzymatic activity could be identified so far maybe exerting a dominant negative effect 26