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doi: 10.1016/j.alcohol.2009.10.011

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid - O -acylceramide

Symptoms may improve, yet the tissue remains fragile
These agents can raise blood pressure and blood sugar, so can be a problem for those with uncontrolled hypertension or uncontrolled diabetes mellitus
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Fewer than 30 total patients have been studied across all published BPC157 human trials
