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Supplementary material The Supplementary Material for this article can be found online at: References 1 TaylorMDNorthcottPAKorshunovARemkeMChoYJCliffordSCet al

however, Tientine demonstrated a more significant inhibitory effect, primarily by suppressing angiogenesis and enhancing apoptosis within the tumors

Nature Genetics, 37, 12641269

10.1002/mrd.23646 18 HouW.XieY.SongX.SunX.LotzeM

doi: 10.1186/s12890-021-01712-2

The liver plays a central role in BBR metabolism via oxidative demethylation and glucuronidation, mainly through cytochrome P450 enzymes such as CYP2D6, CYP1A2, and CYP3A4 [15,20]
