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(2021) demonstrated that activation of BNIP3-mediated mitophagy attenuates dopaminergic neuronal damage in both MPP + -tinduced cells and MPTP-induced Parkinsons disease mouse models

Work by Goldstein and colleagues, who first characterised the thymosin family of peptides, established thymosin beta-4 as a major actin-sequestering protein with roles in wound healing and anti-inflammatory signalling

[PubMed: 11893773] 108

In addition, at high concentrations calcidiol can displace calcitriol from vitamin D binding protein resulting in increased free calcitriol that can then activate the VDR

When it loses integrity, the barrier becomes more permeable and that increased permeability is precisely what leaky gut is meant to describe

2003;133(11 Suppl 2):3972S80S