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ROS may also mediate metabolism reprogramming ( Classical strategies include direct/indirect HIF targeting and interference in upstream/downstream HIF regulators/signaling pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] Fontaine J.X., Terc-Laforgue T., Armengaud P., Clment G., Renou J.P., Pelletier S., Catterou M., Azzopardi M., Gibon Y., Lea P.J., et al

Zamudio J.R., Mittra B., Wohlschlegel J.A., Sturm N.R., Campbell D.A., "Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex", Mol Cell Biol 5: 1202-1211 (2009)

GDF-15 neutralization alleviates platinum-based chemotherapy-induced emesis, anorexia, and weight loss in mice and nonhuman primates

In an open-labeled human study, BM (two capsules/day containing 320 mg of dried extract of BM whole plant) was supplemented to 35 cognitively healthy, aging (60-78-year-old) control subjects over 3 months to identify its impact on safety and cognitive aging and molecular markers

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