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When copper accumulates excessively or is improperly transported, the disruption of copper homeostasis causes cellular toxicity when copper concentrations in cells exceed the threshold that homeostatic mechanisms can tolerate (123)

Chang H, Park JH, Min KH, Lee RS, Kim EK

Not equivalent potency but better safety profile for long-term use

Yet it would take several decades before compelling evidence from epidemiological studies, such as Framingham (221) and MRFIT (222), demonstrated that elevated blood cholesterol levels were associated with increased risk of cardiovascular events (CVE)

The importance of this use case cannot be overstated for both the aging population, who rapidly lose muscle mass and function as a result of immobility [96], and the military population, who are at increased risk of muscle degradation or injury during training and combat [97, 98]

Molina-Molina M