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PARP: Poly (ADP-ribose) Polymerase

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Its impact on CYP2E1, CYP2A1/2A2, and CYP2B1/2B2 has been demonstrated within the central nervous system (Zevin and Benowitz, 1999)

After APAP overdose, cytokines, such as tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6), and chemokines, such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein 2 (MIP-2), were detected in the plasma of animals and patients

Undifferentiated HepaRG cells were obtained from Biopredic International (Rennes, France) and were cultured as described before 73