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The characterization of an acetylator phenotype in humans was one of the first hereditary traits identified, and was responsible for the development of the field of pharmacogenetics ( see Chapter 7 )
& Leaver, C

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1a, normal SD rats were placed in open field boxes to compare baseline and peptide-induced locomotor activities among the three treatment groups ( n = 68 animals per group)

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This difference in protein regulation reflects an interaction between APOE genotype and sex and the role of hormone and chromosome differences to this effect remains to be explored
