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Mansour et al., 2009)

In certain breeds of dogs, B12 deficiency can be genetically passed on especially in beagles, border collies, and giant schnauzers

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AST-IV protected microglia from lipopolysaccharide-evoked death and down-regulated the release of pro-inflammatory mediators, including interleukin IL-1 , IL-6, tumor necrosis factor (TNF- ), and nitric oxide, as well as, expression of Toll-like receptors 4 (TLR4), MyD88, and NF-B [137]

M., Cho, S., Sternlieb, I., Scheinberg, I