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A growing body of evidence based on meta-analyses, observational prospective and retrospective studies, and interventional studies has shown associations between hypovitaminosis D and the occurrence of acute severe COVID-19, including an elevated risk of admission at the ICU, length of stay at the ICU, need for mechanical ventilation and mortality [75,273,274]

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These results indicate that the metabolic shift from glucose substrate-dependent pathway to FAO or glutaminolysis was induced under the exposure to H 2 O 2 regarding the mitochondrial damage, whereas the promotion was not enough to compensate respiratory capacity decrease and was rather a marker of H 2 O 2 -exposed stress, and this shift was held to the nearly normal state with PQQ pretreatment protection

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