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By contrast, softer compounds offer greater grip in exchange for less wear

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Beyond potential direct receptor-mediated effects, it is more plausible that GLP-1RAs influence thyroid physiology indirectly by modulating systemic inflammation, adipokine signaling, and immune tolerance, thereby affecting the autoimmune milieu rather than acting on thyroid tissue itself [9]

doi: 10.1038/ki.1993.372 82 YuenKCJBillerBMKRadovickSCarmichaelJDJasimSPantaloneKMet al