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[91] found that early-life fisetin administration enhanced glucose metabolism, cognitive function, and reduced SASP expression in male mice, indicating sex-dependent responses to preventive interventions

Oxidative stress, which is resulted from an imbalance between the production of free radicals and the ability of antioxidant defense mechanism to deactivate them, is involved in the development of many chronic diseases such as cancer, diabetes, CVD and some neurodegenerative diseases

The Nrf2-Keap1-ARE signaling axis plays a crucial role in antioxidant defense and is also effective in defense against tumor development

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