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Treatment starts at 0.25 mg weekly and increases every four weeks through 0.5 mg, 1.0 mg, and 1.7 mg before reaching the maintenance dose of 2.4 mg per week

People with a known allergy to cobalamin or cobalt should avoid them, and those with Leber's hereditary optic neuropathy should not receive B12

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For gut or systemic inflammation, local skin placement matters less

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