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2008 Aug;128(8):1203-7

plantarum JM113 increase the activity of antioxidant enzymes such as SOD and CAT, thereby reducing oxidative stress and apoptosis

Long-term replacement therapy in adults with growth hormone deficiency (GHD) of either childhood- or adult- onset etiology

Powell et al., 1991)
Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 (Xiao et al., 2021)

Dehydration, kidney issues, diarrhea, too much exercise, and ketoacidosis may also be potential culprits
