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Also, the body burden of cadmium, mercury and lead in the cortex is not associated to the level of known soluble biomarkers of oxidative stress, such as 8-oxo-deoxyguanosine [176]

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have evidenced an initial GSH increase, followed by a progressive depletion [99]

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Study design Data were collected at baseline (initial screening) and again at 48 months after the initial screening

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