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Standard lupus treatment remains the foundation of disease control, while cell therapy may be considered only as an additional option in selected cases

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In vitro studies have utilized human umbilical vein endothelial cells (HUVECs) to investigate angiogenic activity, human fibroblast cultures for wound migration assays, and tendon fibroblast primary cultures to examine collagen synthesis rates

Moreover, research has demonstrated that cobalamin is not only essential to this process but also actively promotes the expression and synthesis of the components necessary for the formation and repair of the myelin sheath [76]

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