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In Vivo Studies In a pioneering work on HD with rutin in 3-NP-treated rats, Suganya and Sumathi reported that oral administration of rutin (25 mg/kg and 50 mg/kg) significantly decreased protein oxidation and improved endogenous antioxidant defence system

R: MMBR 121 ParkB.HwangH.ChangJ.HongS.LeeS.JungM.et al (2017)

Sperm cells with impaired morphology, mainly with cytoplasmic residues indicating their immaturity and reduced fertility potential, produce higher amounts of ROS than spermatozoa with normal structure [26, 27]

Luckily, topical application of Vitamin C curbs melanin production, waning this discoloration

Three aromatic compound degradation pathways (cluster 12) were enriched across all pairwise comparisons: catechol degradation to ketoadipate, catechol degradation III (orthocleavage pathway), and aromatic compounds degradation via ketoadipate