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Eisner MD, Anthonisen N, Coultas D, Kuenzli N, Perez-Padilla R, Postma D, Romieu I, Silverman EK, Balmes JR: An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease

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They tend to act as signals or hormones rather than as folded machines

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For single-use reconstitution where the entire volume will be used immediately, sterile water is appropriate
