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10.1021/acs.biomac.6b00183

Since the report of two pharmacological agents in the late 1950s, the pathophysiology of MDD has been linked to a depletion in monoaminergic neurotransmitters, such as noradrenaline, serotonin and dopamine ( Since melatonin production occurs from serotonin after stimulation of adrenoreceptors (see section What Is the Pathway of Melatonin Production

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Therefore, molecular characteristics determine delivery method suitability more than anything else

[DOI] [PMC free article] [PubMed] [Google Scholar] 268.Wallace J.L., McKnight W., Del Soldato P., Baydoun A.R., Cirino G