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Footnotes AUTHOR CONTRIBUTIONS: X.Y

Instead of just focusing on calories in and calories out, this approach addresses the underlying biological reasons why weight loss has become so challenging

Persistent neuroinflammation may disrupt the 5-hydroxytryptamine (5-HT) signaling pathway, exacerbate neural dysfunction, and, through a positive feedback mechanism, impair neural circuit remodeling and synaptic plasticity, thereby contributing to the comorbid progression of both disorders

The six weeks of trying not to make it worse start now: the careful door handles, the avoiding handshakes, the watching everyone else send while you ice a finger and read about pulley grades at midnight

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