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Hemizygous mice over-expressing wild-type hSOD1 (hSOD1WT) did not show the ALS-like phenotype, but did show it when crossed with GCLm-knockout mice, with a 7080% decrease in total GSH levels [115]

The albumin quotient (Q alb ), a key marker of BBB permeability, has been found to be elevated in several studies involving individuals with preclinical AD, mild cognitive impairment (MCI), and established AD itself (Halliday et al

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