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doi: 10.3389/fimmu.2019.00925

& Nema, S

Lancet Oncol 16(9):e422, 2015

Coumarin was first isolated from tonka beans in 1820 by Vogel, who initially misidentified it as benzoic acid

Nat Rev Drug Discov 19, 609633

Consider the clinical reason for using it, ingredient identity, dose, manufacturing quality, stability, storage, tolerance, cost and whether the product is producing a meaningful benefit