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Interestingly, in another study, although F1 generation offspring did not develop obesity, both male and female F3 generation were obese and presented differential DNA methylation in genes associated with this comorbidity [123]

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Compared with baseline, the results showed a significant increase in collagen fiber network (fiber cross-linking and fiber length) along with a significant increase in epidermal hyaluronic acid levels

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Interestingly, their effects on GH synthesis seem to be concentration-dependent, as low and high concentrations of nesfatins downregulate the expression of GH mRNA, while medium concentrations of nesfatins does not produce this effect (443)