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Moreover, glutamine-induced activation of mTORC1 results in the phosphorylation of the enzyme complex called carbamoyl phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), which catalyzes the condensation reaction converting glutamine-derived nitrogen into the pyrimidine precursor orotate 34,35

doi: 10.3389/fendo.2022.1015520 30 De RosaMZarrilliSDi SarnoAMilanoNGaccioneMBoggiaBet al

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Diabetic neuropathy and oxidative stress

Biochemistry of proinflammatory macrophage activation