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At the presynaptic level, misfolded syn aggregates accumulate in the terminal, binding to membranes and altering curvature [195]
This mechanism aids in reducing the burden of toxins on various organs, particularly the liver, and supports overall cellular health and function

The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research

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