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Description
Cafestol may protect against diabetes-associated myocardial fibrosis, given that it mitigates against increased collagen synthesis, transforming growth factor-1 production, and Smad2/3 phosphorylation (seen on exposure to high glucose conditions) in rat cardiac fibroblasts [69]
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Due to its properties, it is one of the popular research peptides used in modern biochemical and hormonal research
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For CRISPRa experiments, guide RNAs were designed to target upstream of the transcriptional start site
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