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Clinical studies have shown increased kynurenine concentrations and higher kynurenine/tryptophan ratios in colonic and ileal lesions of patients with IBD compared to those in healthy controls, probably due to increased IDO1 expression [62, 63]

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Individuals who follow a strict vegan diet are at a higher risk since they exclude animal products such as meat, fish, eggs, and milk, which are rich sources of B12