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Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics
Precipitating factors include gastrointestinal bleeding, uremia, sedatives, diuretics, protein overload, infection, constipation, dehydration, and electrolyte imbalance

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doi:10.1113/jphysiol.2010.201343

This aligns supplementation with periods of higher energy demand when fatty acids are actively being used for fuel
